The Resource Translational Biology in Medicine

Translational Biology in Medicine

Label
Translational Biology in Medicine
Title
Translational Biology in Medicine
Creator
Contributor
Subject
Genre
Language
eng
Summary
The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods are presented, including studies in aging, tissue repair and chronic infection, each with an emphasis on how personalized medicine is transforming biomedicine. Bioethical considerations in translational study design and bioethical considerations in biomedical research are then covered, before concluding remarks, and a look towards the future of personalized medicine. Describes cellular and animal model systems used in translational research Discusses the use of blood, genetic and genomic biomarkers for disease Presents translational studies in aging, tissue repair and infectious disease biomedicine
Member of
Cataloging source
MiAaPQ
http://library.link/vocab/creatorName
Montano, M
LC call number
R850 -- .M668 2014eb
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
ProQuest (Firm)
Series statement
Woodhead Publishing Series in Biomedicine Ser
http://library.link/vocab/subjectName
  • Medical innovations
  • Medicine, Experimental
Label
Translational Biology in Medicine
Link
https://ebookcentral.proquest.com/lib/multco/detail.action?docID=1903774
Instantiates
Publication
Copyright
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Cover -- Translational Biology in Medicine: Models from aging, muscle regeneration and infection -- Copyright -- Dedication -- Contents -- List of figures -- Abbreviations -- About the author -- 1 Introduction and overview of chapter contents -- 2 Model systems -- 2.1 Introduction -- 2.2 Immortalized cell lines -- 2.3 Primary cells obtained from the host -- 2.4 Animal models -- 2.5 Stem cells: adult and induced pluripotent -- 3 Blood biomarkers: overview of existing serum test strategies for disease severity, risk for progression, therapeutic benchmark targets -- 3.1 Introduction -- 3.2 Early definition of biomarkers -- 3.3 Initial biomarker discovery -- 3.4 Translation into animal models -- 3.5 Translation into small human populations -- 3.6 Application to larger, more generalizable populations -- 3.7 Biomarker measurement considerations -- 4 Genetic and genomic profiling -- 4.1 Introduction -- 4.2 Theories of heritability of disease risk and severity -- 4.3 Gene expression signatures -- 4.4 Examples of gene expression signatures -- 5 Translational models, methods and concepts in studies of aging and longevity -- 5.1 Introduction -- 5.2 Theories of aging -- 5.3 The here and now: the world is aging -- 5.4 Telomere length/activity in aging -- 5.5 Stem cell aging -- 5.6 Aging and muscle tissue regeneration -- 5.7 Immune aging and immunosenescence -- 5.8 The insulin/IGF1 signaling axis in aging -- 5.9 Branched-chain amino acids (BCAA) and aging -- 5.10 Measurement of lifespan modulators -- 5.11 Factors influencing aging -- 6 Translational models, methods and concepts in studies of muscle tissue -- 6.1 Introduction -- 6.2 Muscle maintenance and regeneration -- 6.3 The role of satellite cell activity in aging and decline in muscle function -- 6.4 Muscle growth regulatory pathways -- 6.5 Sarcopenia and muscle maintenance
  • 6.6 Functional limitations and therapeutic drug design -- 6.7 The TGFb1 axis -- 6.8 Inflammatory stress and muscle -- 6.9 Cachexia and muscle homeostasis -- 6.10 Anabolic effects of testosterone treatment -- 6.11 Use of high-throughput technologies with muscle to promote musculoskeletal growth -- 7 Translational models, methods and concepts in studies of acute and chronic infection -- 7.1 Introduction -- 7.2 From HIV origins to the modern era -- 7.3 HIV infection and aging -- 7.4 HIV-1 infection and transmission -- 7.5 Infection and innate host response -- 7.6 HIV and adaptive host response -- 7.7 HIV-1 comorbid conditions -- 7.8 HIV and drugs -- 7.9 Infection-associated inflammation and aging promote fibrosis -- 7.10 Viral eradication studies -- 8 Bioethical considerations and institutional review board (IRB) challenges in translational study design and bioethical considerations in biomedical research -- 8.1 Institutional review boards -- 8.2 Institutional animal care and use committee (IACUC) -- 8.3 Big Data and the online privacy of health information -- 9 Concluding remarks and the future of personalized medicine -- 9.1 Introduction -- 9.2 Personalized medicine and aging -- 9.3 Personalized medicine and muscle maintenance -- 9.4 Personalized medicine and infectious diseases: HIV -- References -- Index
Control code
EBC1903774
Dimensions
unknown
Extent
1 online resource (229 pages)
Form of item
online
Isbn
9781908818652
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2018. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
Sound
unknown sound
Specific material designation
remote
System control number
  • (MiAaPQ)EBC1903774
  • (Au-PeEL)EBL1903774
  • (CaPaEBR)ebr11000101
  • (CaONFJC)MIL679158
  • (OCoLC)898326883
Label
Translational Biology in Medicine
Link
https://ebookcentral.proquest.com/lib/multco/detail.action?docID=1903774
Publication
Copyright
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Cover -- Translational Biology in Medicine: Models from aging, muscle regeneration and infection -- Copyright -- Dedication -- Contents -- List of figures -- Abbreviations -- About the author -- 1 Introduction and overview of chapter contents -- 2 Model systems -- 2.1 Introduction -- 2.2 Immortalized cell lines -- 2.3 Primary cells obtained from the host -- 2.4 Animal models -- 2.5 Stem cells: adult and induced pluripotent -- 3 Blood biomarkers: overview of existing serum test strategies for disease severity, risk for progression, therapeutic benchmark targets -- 3.1 Introduction -- 3.2 Early definition of biomarkers -- 3.3 Initial biomarker discovery -- 3.4 Translation into animal models -- 3.5 Translation into small human populations -- 3.6 Application to larger, more generalizable populations -- 3.7 Biomarker measurement considerations -- 4 Genetic and genomic profiling -- 4.1 Introduction -- 4.2 Theories of heritability of disease risk and severity -- 4.3 Gene expression signatures -- 4.4 Examples of gene expression signatures -- 5 Translational models, methods and concepts in studies of aging and longevity -- 5.1 Introduction -- 5.2 Theories of aging -- 5.3 The here and now: the world is aging -- 5.4 Telomere length/activity in aging -- 5.5 Stem cell aging -- 5.6 Aging and muscle tissue regeneration -- 5.7 Immune aging and immunosenescence -- 5.8 The insulin/IGF1 signaling axis in aging -- 5.9 Branched-chain amino acids (BCAA) and aging -- 5.10 Measurement of lifespan modulators -- 5.11 Factors influencing aging -- 6 Translational models, methods and concepts in studies of muscle tissue -- 6.1 Introduction -- 6.2 Muscle maintenance and regeneration -- 6.3 The role of satellite cell activity in aging and decline in muscle function -- 6.4 Muscle growth regulatory pathways -- 6.5 Sarcopenia and muscle maintenance
  • 6.6 Functional limitations and therapeutic drug design -- 6.7 The TGFb1 axis -- 6.8 Inflammatory stress and muscle -- 6.9 Cachexia and muscle homeostasis -- 6.10 Anabolic effects of testosterone treatment -- 6.11 Use of high-throughput technologies with muscle to promote musculoskeletal growth -- 7 Translational models, methods and concepts in studies of acute and chronic infection -- 7.1 Introduction -- 7.2 From HIV origins to the modern era -- 7.3 HIV infection and aging -- 7.4 HIV-1 infection and transmission -- 7.5 Infection and innate host response -- 7.6 HIV and adaptive host response -- 7.7 HIV-1 comorbid conditions -- 7.8 HIV and drugs -- 7.9 Infection-associated inflammation and aging promote fibrosis -- 7.10 Viral eradication studies -- 8 Bioethical considerations and institutional review board (IRB) challenges in translational study design and bioethical considerations in biomedical research -- 8.1 Institutional review boards -- 8.2 Institutional animal care and use committee (IACUC) -- 8.3 Big Data and the online privacy of health information -- 9 Concluding remarks and the future of personalized medicine -- 9.1 Introduction -- 9.2 Personalized medicine and aging -- 9.3 Personalized medicine and muscle maintenance -- 9.4 Personalized medicine and infectious diseases: HIV -- References -- Index
Control code
EBC1903774
Dimensions
unknown
Extent
1 online resource (229 pages)
Form of item
online
Isbn
9781908818652
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2018. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
Sound
unknown sound
Specific material designation
remote
System control number
  • (MiAaPQ)EBC1903774
  • (Au-PeEL)EBL1903774
  • (CaPaEBR)ebr11000101
  • (CaONFJC)MIL679158
  • (OCoLC)898326883

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